To add injury to insult, Liverpool look likely to lose yet another player for a lengthy spell to a dislocated shoulder suffered in a humiliating defeat by Tottenham Hotspurs.
The defender took on ex-team mate Peter Crouch in the dying minutes of the game which left him grounded.
The team had scored a well deserved 42nd minute lead but soon gifted their opponents an own goal equaliser in the second half after Defoe missed a penalty.
Manager Roy Hodgson believes the loss of their key centre-back left the team wide open to Aaron Lennon's late winner in the closing stages of the game.
The misery went further when it was revealed Carragher had suffered a dislocated shoulder for which a recovery period has not yet been set.
With Agger down and Carragher now off the pitch Liverpool are falling short of centre halves.
The new gaffer also explained his disappointment at having come away from the game with nothing and a potentially turbulent near future.
Club skipper, Steven Gerrard, is also out with a hamstring injury leaving the struggling side without two of their key international players and lifeblood of the club.
Liverpool have already faced a difficult season with a major controversial transfer of ownership, new manager and an unfortunate bout of injuries possibly contributing to a series of defeats which leaves them in a disappointing 10th place in the league.
Liverpool had been set to make some headway in the European cup but with this series of events they will struggle to match previous success.
At one point this season they were looking to end up dead last in the league table.
Spurs also suffered aren't exactly fortunate in comparison; they are missing central defenders Michael Dawson, Ledley King and Jonathan Woodgate and could even lose Younes Kaboul if his torn hip muscle turns out to be serious.